Hello @thoren, Welcome to Connect. It is great that you are able to be an advocate for your wife in finding something to give her relief from her pain and helping her improve her sleep. Here are two articles you might find helpful for tips when neuropathy symptoms are affecting sleep.

-- Tips to Reduce Peripheral Neuropathy Pain and Improve Sleep Quality: https://fapnewstoday.com/2020/02/12/neuropathic-pain-sleep-quality-tips/
-- Are Neuropathy Symptoms Affecting Your Sleep?: https://www.everydayhealth.com/neurology/neuropathy/are-neuropathy-symptoms-affecting-your-sleep/
-- Managing & Coping with Neuropathy: https://www.foundationforpn.org/living-well/lifestyle/managing-peripheral-neuropathy/

You may also find the following discussion helpful to learn what others have shared about their neuropathy journey — Member Neuropathy Journey Stories: What's Yours?: https://connect.mayoclinic.org/discussion/member-neuoropathy-journey-stories-whats-yours/

Are you able to share a little information about the medications your wife is taking for neuropathy?

This is what I do: Get your Dr or another to prescribe 120 tablets (a 30 day supply) Oxicodone APAP 5/325. DO NOT OVERU5E S this is a rigidly controlled substance by your pharmacist❗️Take one with abundant glasses of water every 4 hours, for instance 8AM, 12, 4, 8. Take an over the counter stool softener along with each pill as this is the principal side effect. Warm baths, application of Aveeno moisturizing lotion to affected limbs as needed with massage is helpful. Consume 1 sleepaide pill at bedtime if needed.
I hope this helps.

opioid patch saved my sanity and my life

Kratom really helps.

Hi. For idiopathic small fiber neuropathy, I am prescribed:

Gabapentin 600 mg 3X

Nucynta 50 mg 4X

Nucynta ER (extended release) 100 mg 2X

Nucynta is a combination of opiod and norepinephrine reuptake inhibitor

My pain is very well-managed with these meds.

I hope you find a way…