Thank you Chris, I have been taking Gabapentin for approx 5 yr, 300 mg 4 X a day with oxycodone 10 mg 4 X day. I was wondering if duloxetine would work better for me as the gabapentin makes me fuzzy and unsteady and unable to think ect. Its my understanding that duloxetine is a antidepressant and I am already taking Zoloft, do you know if the duloxetine could replace the Zoloft. I am desperate to try anything as the pain is unbearable at times. It was in late afternoons and now its all day but worse at night and in feet and in past 6 months has moved up to below knees, I also have RLS and when the two set in at same time, I walk the floors and cry. Thanks Chris for being there for all of us who suffer this disease Hope you are rewarded and have a blessed day. Zailey