@artscaping thank you for your reply and insights. I am able to take the med in the morning, it actually doesn’t seem to be bothering me GI wise which is funny because a lot of meds do. With the duloxetene, I’ve had excessive yawning and a hyperactive gag reflex, although those 2 effects seem to have gotten better after first couple of days. I still have a lot of profound sleepiness at times and just a foggy feeling, but ironically am not sleeping well at night. Headaches and jaw clenching/teeth grinding, which I suspect is causing muscles in my face to feel weak and twitchy, or possibly the med is causing that directly. I also feel very irritable. As I said, I’ve been pleasantly surprised that the duloxetene had a really quick (1st day) effect on my pain and neuropathy. I wasn’t expecting that, as this class of drugs normally takes a while to have efficacy. So, I really would like to continue it if possible. After 5 days I feel like it’s too early to give up but quality of life at the moment is not improved, even though I have the symptom relief! Thanks again.