I never connected the use of Prednisone in combination with Melatonin, but I began to miraculously feel better this past late winter /early spring, and that was when I decided to toss the melatonin. I was not sleeping...only two hours a night, and I was exhausted. So I began to take it, and held onto it for quite some time. Never have regained my old wonderful sleep pattern, but when I was hospitalized I decided to put my stimulus check money back into the economy and we bought adjustable beds for myself and hubby. We got twins because at our age bed care could happen, and we're forward thinking. I'm now able to sleep about 6 hrs. a night, and once in a great while 8 hrs. Now I'm wondering how much that melatonin was interfering with my pred. I was telling others that something miraculous was going on because I was feeling so much better. I have much better cognitive ability than I had when I was in a constant brain fog. I'm like my old self only with bad knees. LOL I have amazing mental clarity back.