Your wife's journey sounds very similar to my husband's. Diagnosed May 2109, 12 folfirinoc rounds, then radiation, then Whipple with clean margins. Ca19 9 slowly rose over the next year and is now at 8 000 so he just started single agent Gemcitabine to avoid further neuropathy side effects. Three treatments one week apart and then a week off. Even though no tumor is visible the rising ca 19 9 is indicative of recurrence. We are praying this new drug helps, so far only side effect has been extreme fatigue for a few days. Good luck to us all!