I have looked at comments posted on the Osteoporosis Foundation discussion forum. One person repeated helpful information about avoiding the acute phase reaction. It includes recommendations about Tylenol and vitamin D. Others have included suggestions about serious hydration before hand and adequate Calcium supplements:
'Here is part of a post entered by a member called Endodoc some time ago. :
"I'm pleased that your physician's recommended Tylenol; (acetaminophen) in addition to being well hydrated when you have your Reclast infusion. I always instruct the infusion nurses to provide 2 acetaminophen tablets (total 650 mg) to patients before the start of the infusion, and instruct the patients to then take the same dose with dinner & at bedtime the day of the infusion, with all 3 meals and at bedtime the following day, and a final dose at breakfast the 2nd morning after the infusion. Taking these 7 doses of "Tylenol" reduces the risk of a symptomatic APR (acute phase response, e.g., fever & muscle/bone aches & pains) from about a 20% (1 in 5) chance down to less than 1%. Also, it is imperative to know your vitamin D level before getting the infusion (assuming it hasn't been checked in the past couple of years). As the treatment is rarely (if ever) an emergency, i always make sure my patients have vitamin D levels in the mid-optimal range (around 40-50 ng/mL) prior to bisphosphonate therapy (especially Reclast). Even if one's level is 18, 5-6 weeks of replacement can bring it up to > 30 ng/mL."'

I received my first infusion of Reclast on March 23, 2022. I asked my endocrinologist to please put in an order to the location where, I was to receive the infusion to have a longer time than the recommended 15 minutes. The endocrinologist placed an order with them for the infusion to last for one hour. I also contacted my allergist and he recommended that I take Claritan, Pepcid and Zyrtec the day before, the day of, and the day after my infusion along with taking 64 ounces of water the day before, the day of and the day after. It is April 16th and so far I have not experienced any side effects. I am so very grateful, because I had severe bone, muscle and joint pain after my second injection of Prolia.
I am requesting anyone to give me any information they have about taking the booster shot for COVID. I got the first booster shot the recommended six weeks after my second injection of Prolia and had severe pain in my joints, muscles and bones. My doctor said the booster exaccerbated the side effects I was already experiencing with the Prolia. I had two months of sever pain after that booster and have switched to Reclast. I am fearful of the side effects I may have if I get the booster. Does anyone have any experience getting the booster who is now on Reclast. I had no problem with the initial COVID vaccination however I was not on Prolia when I got vaccinated. I asked all of my doctors if it was ok to get the booster while on Prolia and they all said yes. My experience was severe. I am anxious to get the booster but fearful that I will have the same experience I had with Prolia. The vaccinations are wonderful and I am so grateful we have the boosters available. Let me know if you are on Reclast and have gotten the booster.
Thank you so much