When I asked about estrogen hormonal levels I got the answer they really do not know what levels mean. If they were going to do levels they should have done a baseline before starting the drug. My frustration with A1 drugs is not only do they have significant side effects but despite thousands of women who are on these drugs they seem unable to state which women are at risk for side effects. Is it age, is it type of breast cancer, is it BMI, is it women who still have their ovaries. I am glad to see that someone is looking at dosage of these drugs because the concept of one size dose fits all seems not very scientific. Can you have the same efficacy at lower doses. Would lower doses mean lower side effects. The fact that 30-40% of women quit this therapy because of side effects is mind boggling. I have this feeling that all they want to do is treat side effects with other meds that have side effects instead of really looking at who is at risk and how to improve this therapy