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Hi Ted @ttl1520, I have degenerative arthritis in my left knee and have had my right knee replaced two years ago due to the arthritis. I also have small fiber peripheral neuropathy in my feet plus I have to wear compression socks because of lymphedema swelling in the legs. I try to exercise daily because it really helps mentally and physically but I don't over do it until I'm tired.
Here's some information on your question -- Excerpt from link below -- "Inflammation, pain, inactivity and lifestyle factors can cause extreme tiredness when living with arthritis. Everyone gets worn out from time to time." -- Causes of Fatigue in Arthritis - Arthritis Foundation: https://www.arthritis.org/health-wellness/healthy-living/managing-pain/fatigue-sleep/causes-of-fatigue-in-arthritis
My neurologist didn't do the skin punch biopsy either but I was OK with that because the EMG and physical exam were enough to determine my diagnosis. Here's more how and why info for the test.
Diagnosing Small Fiber Neuropathy Through the Use of Skin Biopsy: https://practicalneurology.com/articles/2009-oct/PN1009_06-php
Did your neurologist diagnose you with neuropathy?
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Hi John. Thanks for replying and the websites. My neurologist did not diagnose neuropathy. Muscle and large nerve tests were negative. Last summer my foot started to hurt me. Almost all of a sudden. before I saw the neurologist. I went to see a local orthopedic clinic. They took x rays. Lots of arthritis in my left foot. Some of the bones are not attached anymore. Said I had it for about 30 years and was surprised, I was complaining now. Go figure that out. Some starting in my right foot. My knee started about 11 years ago. I have been managing the pain with Aleve, CBD cream & EMU oil cream. I didn't tire very easily. But in March, fatigue started to set in. My regular doctor tested the blood flowing my feet. Ok. Said may I had shin splints. I am due to go back to him for a wellness physical. See what happens. I have been wondering if maybe I had an asymptomatic Covid.