Yes, I have spent thousands and thousands of dollars with naturopathic doctors, therapists, acupuncturists, tens units, etc. I have tried Naltrexone, Tramadol, Cymbalta, Lyrica, etc. For me a combo of lyrica and an opioid patch has controlled my pain to a level three the past few years. I know everyone is different. My pain is not something that is intermittent. It is constant. My legs have not felt the same since I developed this disease. Mine is considered idiopathic neuropathy. I have been tested for everything at the university and nothing is positive. All blood tests were negative. My doctor thinks I could possibly pre-diabetic. Who knows. For me it came on after a virus and never left. I have asked my neurologist about every so called "cure" for neuropathy and he said there is none. He will not even recommend IVIG. Not sure why. Thank God I have good doctors willing to treat my pain. I don't know what I would do without them. Best of luck.