Hello @drlovegrove, Welcome to Connect, an online community where patients and caregivers share their experiences, find support and exchange information with others. Thanks for sharing your story with PMR. Nausea is one of the side effects listed under Methotrexate that you should contact your doctor immediately if it occurs.

Methotrexate Side Effects: https://www.drugs.com/sfx/methotrexate-side-effects.html

Was the Methotrexate prescribed for your PMR when you tapered off of prednisone?