@mjay Hi - I too started the Arimidex (anastrozole) in late October 2019 along with Verzenio. Absolutely no big deal - could not be more active with great numbers. Managed the GI and nauseous with a good diet of well balanced food. Hair loss/thinning started and I jumped on to the Biotin gummies of Hair, Sin and Nails. But in Feb/March this year weirdly started getting debilitating back pain, that went away then foot pain but that stopped, then knee, then belly. My numbers budged a bit. I felt like a “complainer” to myself and to my doc. I mean as we age who doesn’t get some aches & pain. However I didn’t want to accept this new “stage”. So my doc not pulling me off yet. He is using all my aches & pain as an excuse to do a complete (I mean complete) body work up. We are thinking something percolating in my case. So I don’t want to scare you or anyone else. But the docs always suspected my meds would stop working. But we weren’t sure how it would “announce” it. Also we have talked about how it could be med side effects but my team felt like this was a good as time as any to do a complete workout - eliminate what we can, etc. And importantly getting on top of anything early before it can settle. So everyone who starts to experience “new issues” after handling meds for a good amount of time can hope for medication side effects but doublecheck for the big “C”. No matter what is determined, you will be happy you did.