I have been on Clofazamine for 2 1/2 months and have had minimal side effects. I have not turned orange, but my face does look a little tan. My skin is quite white and I expected the orange from what I had read. The most significant side effect has been weight loss and digestive issues. I have lost another 5 lbs on Clofazamine, and I am working hard to gain some back. My digestion was not good anyway because of the big 3, so it is hard to discern how much is due to Clofazamine, Like you, I cough up minimal sputum. I lost my voice with amikaycin, and it returned when I stopped taking it, I did not lose it with Arikayce but I only took 4 doses. Overall, I am ok with the Clofazamine, and am just hoping it will get rid of the resistant strain of MAC that I have.