I just finished my third month of single month Lupron injections. The change in mental sharpness motivation, absence of most cramping, muscle and joint pain, has been amazing in my case. Don't know if you will have the same results or not, but all my blood numbers, (PSA and T Levels) have remained the same. I only took one three month dose and it did not affect me enough that I noticed. Hope this helps. I can't wait to get off this crap!