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@creeder

I recently had a lumpectomy after getting a 2nd opinion at Mayo. My former hospital did not catch it! No lymph nodes were affected and margins were considered clear however, the team suggested (as a safeguard) that I have 5 treatments of radiation followed by a low dosage of tomaxifen...5mg every other day. It seems to be a fairly new concept and wondered how others have faired with such a treatment? I guess I am apprehensive concerning the newness of this dosage and want the most successful treatment out there. Any suggestions? I also have a concern with cancer treatment affecting the thyroid meds I have taken for years. Your comments are greatly appreciated.

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Replies to "I recently had a lumpectomy after getting a 2nd opinion at Mayo. My former hospital did..."

Were you prescribed 5 mg of Tamoxifen by a Mayo oncologist? I had no side effects when I took 5 mg every day but my oncologist did not support that as he said there was no data showing that to be effective. Would be very interested to know if there are new studies!

Welcome Creeder. I'm glad you got a second opinion at Mayo Clinic. What led you to seek a second opinion?

@mugs24cancer, researcher as early as 2018 published evidence that low-dose tamoxifen can be effective for intraepithelial neoplasia - early, non-invasive or pre-invasive cancers such as atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS), and lobular carcinoma in situ (LCIS).
- Can Low-Dose Tamoxifen Prevent Recurrences With Reduced Toxicity? https://www.cancernetwork.com/view/can-low-dose-tamoxifen-prevent-recurrences-reduced-toxicity
- 5 mg Tamoxifen as Effective as 20 mg Daily in Early Localized Breast Cancer http://www.theoncologynurse.com/breast-cancer/17686-5-mg-tamoxifen