← Return to Is it safe to get the Corona Virus (COVID-19) vaccine with PMR?

Discussion
Comment receiving replies
@2heal

I got the 1st dose of Moderna on 1/22/21 and within several days experienced severe inflammation in shoulders and hips. Diagnosis was PMR with SED rates @ 50. I fit the profile for PMR (female, late 60's, of Northern European descent), but I feel it was definitely triggered by the vaccine. Neither my Rheumatologist nor my primary physician knew whether to recommend I take the 2nd dose of Moderna, so I haven't. The catch is that I know the prednisone reduces my immunity, and I guess with only 1 part of the Moderna therapy I may have a lesser degree of immunity to the virus.
Have been taking prednisone 2x daily since then, trying to reduce it from 40 mg/day and am now at 22.5mg/day. My reactions to the prednisone seem worse than to the PMR, but my Rheumatology doctor hasn't been able to see me since I saw him in mid February. I am suffering shortness of breath, my face is very swollen, my eyes bother me, my skull feels swollen. I was reducing prednisone every 5 days, but my SED rate increased from my post original therapy of 50 to 22 with Rx, and to 41 during that period when I was reducing it. Pain was not too remarkable in the process though I could feel that shoulder pain was beginning by the time I woke up each day. Since then, on basis of SED rate, I was told to stop reducing prednisone until I could get my first follow up appointment since diagnosis. I'm uncomfortable with the prednisone and really want it reduced as quickly as possible.

Jump to this post


Replies to "I got the 1st dose of Moderna on 1/22/21 and within several days experienced severe inflammation..."

Hello @2heal, Welcome to Mayo Clinic Connect, a welcoming online community where patients and caregivers share their experiences, find support and exchange information with others. From my experience with 2 occurrences of PMR and what some others have said when first diagnosed with PMR is they were started at 20 mg dose of prednisone, I have no medical background or training but I'm wondering if the swollen face and shortness of breath may be a side effect of the high dosage of prednisone. The Drugwatch site lists both of the symptoms you mention as possible serious side effects possibly caused by an allergic reaction to prednisone.

Prednisone Side Effects: https://www.drugwatch.com/prednisone/side-effects/

Have you discussed your symptoms with your rheumatologist or doctor?

I developed symptoms and was diagnosed with PMR after my second Moderna vaccine. Had absolutely no issues prior to the vaccine- my rheumatologist agrees it was the trigger.

So much is not known about immune responses to the COVID vaccine. However, having a strong immune response to the first shot does not necessarily mean you will have the same reaction to the second shot, as @loribmt can attest to in her case.