Hello @arribasally, Welcome to Mayo Clinic Connect. One of the big problems a lot of us have when we are diagnosed with PMR is trying to taper off of the prednisone too quickly. Each of us are different but the name of the game when tapering off of prednisone is to listen to your body and not go down too fast. Since you were diagnosed in Jan 2021 and started at 20 mg prednisone and are now at 12.5 (up from the 10 mg) did the pain show up when you dropped to 10 mg or had you been at 10 mg for some time? Did your rheumatologist suggest a specific tapering schedule?