Hi just doing researching again and saw your post from 2018, I too was on Effexor for 15 years, I weaned off it in Nov 2012 and by March 2013 was my first ER visit that started my eight year chronic pain journey that has destroyed my life, and left me a shell of a person, it has been the mystery of my lifetime, I'm a cancer survivor and fought hard in my twenty's to survive endometrial cancer, after that to a successful business owner, raised my family and enjoyed life and I did suffer from some depression and anxiety and had a few other health issues but not that took away my quality of life and now I am completely bedridden in eight years, I have been to over 30 different doctors trying to get help/answers with all the pain throughout my body, in eight years now I have been diagnosed with Lupus, Chronic Osteoporosis, Osteoarthritis, Cervical Disc Disorder with Radiculopathy, Intercostal Neuralgia, Bilateral Occipital Neuralgia, Costochondritis, Fibromyalgia, Chronic Migraines, Bile Reflux, Meningiomas in my brain, etc. it just goes on. I had none of this before except I did suffer from Migraines all my life. The Pain started in my left ribcage and spread from there, when I went off the Effexor I had gained some weight from it at 175 pounds I am 5 foot tall, my normal weight was about 130, now I only weight 85 pounds because I can't eat much of anything, I have weighed under 100 pounds for four years now, and I've had to have all my top teeth replaced because my jaw bone was shifting and cracking, I had so many procedures and two surgeries, nerve blocks, and trigger point injections 700+ in 8 years, with over 400 just in the last three years all over my body rotated biweekly and I have to be on pain medication and sleeping pills for years, I feel like I will die any day I'm 58 years old, For years Dr. would take blood tests, MRI's, CT's X-rays and tell me I was fine, bloodwork looks fine, test look fine, but I was in so much pain I couldn't stand it, I didn't know why I was loosing weight or feeling such bad pain, I was scared, most dr's made me feel it was all in my head and treated me unkindly, all I was asking for was help I was scared, until the damaged started to show up on the MRI's, labs etc. and my health begin deteriorating and now. I have brought it up many time with dr's I have seen about any connection to Effexor since I had such a hard time getting off of it, but I just get that blank stare or they can't say. I would really be interested to know if anyone else has had anything similar happened to them or someone they know.