I had been on Entyvio (remission for 13 months, then stopped responding). Next biologic was Stelara, which just made things worse. I have been hospitalized 3 times in two months, dehydrated and put on IV steroids. I am currently on high doses of oral prednisone and just started Remicade (had first loading dose infusion last week). I will have the second loading dose on Wednesday and the third 4 weeks after that. If the Remicade doesn't work, I will be scheduling a proctocolectomy because I cannot stay on this roller coaster of hell. I have only had UC a little less than 4 years and it has escalated to pancolitis. My advice would be to talk to your doctor constantly and stay on top of things. Sometimes the biologics take several weeks to work. I have noticed a slight decrease in symptoms since starting the Remicade, so I am almost hopeful.... The prednisone is the worst for me - I shake constantly and I am miserable. This disease has ruined my life. I wish you the best and I hope and pray for a cure for all of us suffering with this unpredictable, debilitating disease.