My experience is with THC/CBD tincture (40:60 I think). I was taking it with Gabapentin (200-300 mg at night typically; both medically prescribed) due to severe cramps caused by liver disease. I found the combination worked well to calm the pain, relax me, and help me sleep. I’ve since had a liver transplant, but now suffer various neuropathy symptoms, severe muscle and joint pain, sharp nerve pains in my legs and feet, etc. Unfortunately both CBD and THC conflict with one of my anti rejection drugs, or I’d definitely continue with the combination, as it worked better for me than just the Gabapentin.