I have had this or something similar for about 2 years. Mine is just below the breasts and seems to run mostly across the chest from side to side in the front, less so in the back. It is a feelin of pressure. I've mentioned it to every doctor (neurologist, gastroenterologist, PCP, etc. with no answer. Finally got my PCP to order a CT scan of the abdomen. Result shows some heart enlargement. Echocardiogram and angiogram of heart show only slight thickening of left ventricle wall which ruled out cardio as a source of this symptom. Cardio also found that I have "monophasic flow" which has to do with blood in lower extremities not flowing back to the heart as it should. I recently started having very low blood pressure. Gastroenterologist did endoscopy and found gastritis and small hiatal hernia. The hiatal hernia seemed to me the most suspect for cause of this mystery feeling. So far nothing prescribed has affected it. When I exert or get stressed (notably having to explain symptoms to my doctors causes me to get out of breath) it becomes much tighter and I FEEL like I can't fill my lungs or take a deep breath, but my oxygen level is normal. I find that I am slumping over when sitting and sometimes when walking and I had suspected this might have to do with the muscles in that area becoming weaker and my posture becoming worse. I also notice that I have to eat smaller amounts of food or the pressure is worse. I'm taking gabapentin for pain and tramadol only as needed. My gastroenerologist prescribed Citrucel and Miralax for constipation and Pepcid and Aloe Vera gelcaps (I guess for the gastritis. My PCP prescribed ezetimibe (Zetia) for cholesterol control. I take vitamin d3 (4000 units a day) and supplemental Calcium (1200 units a day) for osteoporosis. I also get monthly injections of Evenity for osteoporosis. All of which are known to my various doctors. I have also been treated for post-treatment Lyme disease, (probably unsucessfully), which I think may be a factor in my neuropathy. I offer all this information in case any of it corresponds with anyone else's profile.

I am somewhat relieved to hear that others have this chest tightness - that it is not in my head. I am a little surprised it may be one effect of the neuropathy although that makes sense I guess. I am starting PT this week and I hope to find exercises to strengthen my back and correct posture among other things and see if that lessens this feeling.

Thank you to everyone who has reported this and I hope my posting helps too. I wish we could get our doctors to recognize this.