I,too, have severe itching. Especially at night. I am a type 2 diabetic for over 20 years. I'm also a pharmacist's dream customer due to (but not limited to): diabetes with neuropathy in my feet that affects my walking, Parkinsons, restless leg syndrome, Barretts syndrome, high blood pressure (had a triple bypass 7 years ago and have a pacemaker for 11 years), retain water but also have nominal kidney problems that keep my lasix down to 40mgdaily dosage, mild anxiety/depression and other non-fatal ailments. I am 79 years old. I itch mainly at night and it keeps me from sleeping well. I do not have hives or psoriasis but my scratching raises bumps and, sometimes, rough skin patches. In addition to some vitamins, I have daily doses of amaryl, lasix, nexium, sinamet, baby aspirin, toprol xl, lipitor, cozaar, requip, actos, zoloft and lovaza, My scratching causes sores and light bleeding. If anyone has a way to help me relieve this problem, I would appreciate your advice. Hydrocortisone cream 1.0% offers very temporary relief; up to 1 or 2 hours.