I have had Major Depression, Anxiety, ADHD, and PTSD for most of my life. The Major Depression plus alcoholism run in my family. The PTSD is the result of my father's suicide when I was 10 years old which was exacerbated by a recent serious automobile accident. I had been treated for the depression by my primary care physician who gave me only a very small dose of Celexa. This did not help much, of course. After the accident, I started seeing a psychologist and a psychiatrist who put me on a large dose of Zoloft and Adderall. This is making a big difference especially the Adderall which helps with fatigue and the Zoloft with the PTSD. Regarding the ADHD, I had a difficult childhood in school having a short attention span, being unable to concentrate and complete tasks and also having dyslexia. This was back in the dark ages before much was known about ADHD so it went undiagnosed and untreated. I am definitely not creative as so many have said in this forum because of the dyslexia, I guess. The psychologist is using cognitive therapy to help me deal with the anxiety resulting from the accident and with my negative thinking. There again, I think the Zoloft and Adderall are helping with this, too. I am 78 years old so I am not very hopeful for being completely "cured" in the years I have left but being able to concentrate on completing tasks and having a little more energy will mean much.