Hello @wheelerma,

I appreciate your concern and desire to find out what might be causing your reaction. It might be helpful, if you are comfortable doing so, to share with Connect the nature of your reaction. Is it increased anxiety, chills, skin rash, etc.? You mentioned the possibility of Serotonin Syndrome. Is that something that you have had before?

I'm also wondering if you have talked with your prescribing physician about this reaction.

@wheelerma There are numerous past discussions on Cymbalta that I think you would benefit from scrolling through and reading previous discussions, posts, experiences, and suggestions.

I agree with @hopeful33250. In order for to properly connect you we need a little more information so.

May I ask the purpose of the medication serves/symptoms you were having before and what has changed since the introduction of the medication?

I would love to read all that you mention, I just don't know where to look. I have severe pain in my SI area although the cause is Scoliosis, Deg. Disc., Spinal Stenosis, Arthritis and Spondylolisthesis. My pain is constant, usually a 7-8, and then it will go to a 15!! I have to sit down. This is a burning pain from the SI area that goes around to my quadriceps. Pleasel et me know if there is anything else.

Have you tried canabis ? From experience with my wife who suffered from pains and took both cymbalta and Lyrica -the canabis made a major improvement.

It is not legal in Indiana and I would know what to buy or where. Anysuggestions?