Hi @jennia - Welcome to Connect! I've had two TKRs and I'm happy to say both went pretty smoothly - although not without a certain level of pain, frustration and worry. So I can imagine why you are feeling concerned with your titanium allergy. Here are some threads you might find interesting:
https://connect.mayoclinic.org/discussion/stem-cell-therapy-2/?pg=1#comment-301639
https://connect.mayoclinic.org/discussion/stem-cell-therapy-for-arthritic-knees/
https://connect.mayoclinic.org/discussion/need-tkr-and-had-positive-allergy-testing-bone-cement-and-metals/
I'm also going to tag a few people who might have insight: @denver, @okieshan1, @gutthookd, and @johnbishop
Meantime, have you talked to your doctor about stem cell availability where you are located?

Hi @jennia, I would like to add my welcome to Connect along with @debbraw. I had a TKR in April and before I had the surgery I had several blood tests and one was checking for metal allergies which didn't find I had a metal allergy. I would definitely be concerned if I had an allergy. I found some information on ceramic joint replacements. I would talk with your surgeon to see if they have recommendations and then discuss any risks.

CeramTec - Patient Information on BIOLOX® Ball Heads and Cup Inserts:
-- https://www.ceramtec.com/biolox/patient-information/

PubMed - Alternative materials and solutions in total knee arthroplasty for patients with metal allergy
-- https://www.ncbi.nlm.nih.gov/pubmed/18210089

It is wonderful to see all the links to read about non-metal materials and stem cell therapy! I have always believed stem cell therapy to be so expensive? (at least on Medicare). My husband had a hip replaced over a year ago - he had a known allergy to nickel and after the replacement found out he also had an allergy to titanium!!! He is now on Dupixent, since Jan., and it is questionable whether or not that will prevent symtoms. Our allergist says she is trying to get the word out that there is a test for heavy metals that should be used when there is a question about allergies. You need to find out all you can before the replacement Knowing you already have a titanium allergy, to me, would be a red flag!!!!!!

My wife is needing a reverse shoulder replacement. She is allergic to cobalt and nickel. Her doctor has not run across this in their 20 years of practice. He seems to not know how to handle this. Has anyone had this issue? Are there any alternatives to the metal implants available? The doctor states no company will guarantee the implants are free of nickel or cobalt.

Stem cell is expensive and not covered by Medicare. The doctors we work with state there is no conclusive proof that stem cell therapy works.

Thanks for info. We asked about stem cell therapy and were quoted a cost of $7,000 not covered by insurance or Medicare. I have seen a lot of posts on here about stem cell therapy for knee replacements but nothing on shoulder replacements. Does anyone have knowledge of stem cell being used for shoulder joints? The doctor who quoted the price for the shoulder didn’t seem very confident it would work for a shoulder.