Here is Dr. Dinh's reply: The likelihood of a recurrence of ovarian cancer depends on multiple factors, some of the most important factors are: stage of disease at the time of initial diagnosis, your response to chemotherapy, and the cell type of the cancer itself. In regards to your concern for letrozole, you’re right in the fact that does have some side effects. However, at age 77, you have already gone through menopause and have experienced the side effects several decades previously. Thus, from the aspect of menopausal symptoms, my guess is that you will have minimal side effects. Overall, we do think that the side effects from letrozole is relatively minimal, and if your cancer is hormonally sensitive, it is a good bet is to use letrozole to help prevent or slow down a recurrence.