Missy, recurrent seizures, temporal lobe damage from seizures, and anti-seizure medication can all affect memory. Memory loss or trouble processing information can be a side effect with Depakote. I am not aware of Depakote causing permanent memory loss. Since there are multiple factors that can cause or lead to memory loss or cognitive problems in patients with epilepsy, it will be important to discuss your concerns with your neurologist. Further testing may help to differentiate between the possibilities. Another option is to switch from Depakote to another anti-seizure drug that does not have the memory side effects – however, this should only be done if your doctor feels this is a safe approach for you.