From Dr. Trost: Some forms of male infertility have clearly been linked to genetic causes. One test that can identify some known causes is looking for Y-chromosome micro deletions. This test is often not covered by insurance and can range from a few hundred dollars to several thousand dollars. I would say, however, that the far majority of causes of male infertility have not been associated with specific genes. Genetics in general is very challenging because there are so many potential genes which may contribute to infertility, and very few of these have actually been fully identified.