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We were recently told that my husband has Klinefelter's Syndrome and has zero sperm count in the analyses he's had done. We've been told that there is a 50% chance sperm can be found through a testicular biopsy. Is that accurate? If sperm is found for IVF, would we be able to have a viable pregnancy and healthy baby?
Replies to "We were recently told that my husband has Klinefelter's Syndrome and has zero sperm count in..."
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From Dr. Trost: That is correct. There are some estimates that in up to 66% of patients with Klinefelter Syndrome we are able to retrieve sperm. In these cases I usually recommend that the patient be started on a medicine, such as clomiphene citrate, for several months and then consider undergoing a microscopic testicular sperm extraction. This gives you the optimal chance to find sperm. As long as you can find sperm you should be able to achieve a viable pregnancy. This assumes of course that the female partner is able to achieve a pregnancy (younger and BMI < 30 = better success). Typically in cases like this IVF is not possible and ICSI (intracytoplasmic sperm injection) is preferred. That is because typically we only find a small number of sperm and IVF requires a much larger number.