Hello, I am glad to hear you are able to tolerate Lupron better after your initial side effects. I was not so fortunate. I had the same problems you mentioned including get out of bed 5 times a night every night for 3 weeks to go to the bathroom. In addition my I would have hot flashes and at times I was mentally challenged to perform basic everyday routines. Eventually my doctor took me off Lupron and I started on Zytiga with Prednisone. I had to discontinue both when I started having difficulty breathing. At present I have received radiation treatment on L1, T11, and T12. I expect more radiation will be necessary as my PSA number has reached 150. All the best to you.