I'm on xarelto for afib and was on the antibiotics for 14 months. My doctor never said anything about it. You do not want to go on Coumadin (generic warfarin) if you can avoid it. It requires regular testing and interacts with food so some diet restrictions may be required. Some doctors are not comfortable with the newer blood thinners.
Coumadin has been around for more than 60 years. Not saying however that this applies to your doctor.
My I.D. Dr. told me that the reason he did not want me to be on Eliquis, which is just like Xarelto, is because it runs the risk of internal bleeding,when used with azithromycin or rifampin, and hemorrhaging since it cannot be titrated. He said that even though warfarin/Coumadin are old school and you have to be blood tested regularly they can titrate the thinness of your blood so you don’t have the risk of taking that with the rifampin. Have you heard of anything like this?