@olduncledave- Good morning and welcome to Mayo Clinic Connect. My husband's name is Dave and I had to chuckle at your signage. Antibiotics are for bacterias and COVID-19 and its variants are viruses. The CDC advises not to have any other vaccines two weeks before your covid vaccine. There is also some evidence that taking OTC anti-inflammatories immediately before the vaccine can reduce its efficacy. The suggestion is that they might interfere with kick starting your immune system. Recommendations state that if you are taking a medication prescribed by your doctor (s) then continue to take them.

"People should not take a painkiller as a preventive measure before getting a vaccine unless a doctor has told them to, he said. The same goes for after a shot: “If you don’t need to take it, you shouldn’t,” Watanabe said (https://apnews.com/article/painkillers-coronavirus-vaccine-explain-9096ee03e63ef4b8b6b81c1736388027)
https://newsnetwork.mayoclinic.org/discussion/common-questions-about-covid-19-vaccinations-answered/
https://www.cdc.gov/vaccines/covid-19/downloads/pre-vaccination-screening-form.pdf
If you have a serious concern make sure to always talk to the prescribing doctor.

Is there a particular medicine that you are worried about?