@canadiangal In the studies read.. I do not see how bile affects absorption of the Effexor… https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/020699s103s105lbl.pdf … When was the last time you had an appointment with your Primary Care Physician .. Your Weight, Diet, and Diabetes are all big factors in how you feel after a large meal.. The body has so many networks and variables that you need to take a new look at the interactions going on with your Doc. What specialties are available to you where ever you are in Canada..?