I am on Prolia. You really cannot take a vacation from Prolia. Amgen, Prolia pharma company, in the information provided to the patient tells you that stopping Prolia can lead to fractures of the spine. Should you wish to stop Prolia, you must start another osteoporosis medication as a "relay" drug in order to prevent fracturing.(e.g. one of the bisphosphonates). Your doctor will tell you this in advance of starting the drug. The information is found on-line as well.