@duckduck2020, Mayo Clinic is making great advances with BRAF mutated colorectal cancers.
See this article and excerpt
- Identification of actionable alterations in colorectal cancer are leading to the development of novel treatment strategies https://www.mayoclinic.org/medical-professionals/cancer/news/identification-of-actionable-alterations-in-colorectal-cancer-are-leading-to-the-development-of-novel-treatment-strategies/mqc-20491602
"A lot of advancements have been made with regard to BRAF V600E mutations, most notably from the BEACON trial and the ANCHOR study. We also know about FGFR alterations, NTRK and ROS1, and ALK aberrations. We know that up to 50% to 75% of patients may benefit from some type of targeted therapy."

I hope that there is a clinical trial that you can take part in at Mayo Clinic or a participating cancer center.

@nathan45, I think the above link may also be relevant for you. Have you had genetic testing to know if your cancer has specific markers or mutations, such as KRAS, HER-2 or BRAF?