Yes fatigue has been a huge issue. I still cannot do what I used to but walk 2-4 mi / day thank goodness. I also have nerve pain and muscle cramping and spasms in the oddest muscle groups . Anyone else have that? Such as my abdomen, or inner thighs. Not your usual calf or toe cramps. Before diagnosis ( of PMR) I could barely ambulate in the mornings til 2 pm or so. And I lost 10 lbs, unheard of for me. Of course that has all returned with the prednisone.