@contentandwell : Yes, I know that stem cell therapy, as well as PRP injections, are a gamble. And the cost can be significant. I believe stem cell is around +/- $ 6000.00 out of pocket. However, if it works, and avoids/delays TKR by 5 years, that is $ 100.00 per month. Worth it to me. Once the bones in your knee have been cut for the implant, that’s permanent. As I mentioned several times, I have been lucky to not have had any major issues with the TKR, works almost as well as my other knee - but still..... not a fan.