@judyjo Hi Joanne, I was on Arikayce for 1 year, a was always a little horse but nothing to really bother me, the strepfen were fantastic, I had half if I needed them. Also rinse your mouth out after nebulising with Arikayce and have it just before bed so you do not talk until the morning. I think it worked for me while I was on it, I may have to go back on it again soon and I would not hesitate. Take care Heather