Which prescription medication helps you best for peripheral neuropathy

Hang in Jeff. There is a life after PN, but it must be earned. PN is a brain condition and with your intense help by NeuroPlasticity you will learn to overcome pain , itch and anguish for your future. It does require belief and perseverance, but the rewards are great, but only if you hang in. Best regards from Australia.

Hi I’m frank. Does anybody know if Lyrica is a good medication for small fiber Neuropathy?

Thanks for the private message @sunnyflower, I thought I would respond to your message in this discussion so that other members may be able to help. I see so many posts that I am not able to remember which new medication you may have seen and wanted to find the post a member shared. This discussion Which prescription medication helps you best for peripheral neuropathy is new and might have the post you were trying to find. The good news is that is not too large that you can't quickly scan through the posts starting from the beginning of the discussion.

Also, you might want to scan the following articles to see if any of the medications mentioned are what you saw in the post you are trying to find.

- 2019 - The neuropathic pain: An overview of the current treatment and future therapeutic approaches: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431761/

- Updated 2020 - Drugs that relieve nerve pain: https://www.health.harvard.edu/pain/drugs-that-relieve-nerve-pain

- 2020 - Most effective drugs for common type of neuropathic pain: https://www.sciencedaily.com/releases/2020/10/201015173129.htm

Hi @sport1776
I'm sorry for your suffering. I too have PN, so I can empathize.
The first step, as others have mentioned, is to get a specific diagnosis, as there are many forms of PN. Some of the forms of PN are treatable by addressing the underlying cause (if known). In my case, and many others, the cause remains unknown, even after an extensive work up (which is best done by a neurologist).
After the work up, the standard treatment is to start with gabapentin or pregabalin (Lyrica). They both act very much the same. The proper dose is determined by experimenting (with your doctor's advice).
Another commonly used medicine is some form of antidepressant, such as duloxitene (Cymbalta). Again, the proper dose varies with the individual. These types of medicines tend to have a dual effect. They help with depression, which many patients with PN develop. They also seem to have a separate analgesic effect.
There are numerous creams and lotions, some over the counter, that can be tried. Also, alternative methods such as acupuncture, meditation, supplements, vitamins, etc. Barry Shears in this forum discusses neuroplasticity.
It is important to maximize your physical surroundings. If your feet are burning, cool them, and vice-versa. Wear comfortable shoes (Ugg type boots help me the most). I wear flip flops whenever I can (even in the winter, but I live in moderate California). Also, I find my feet hurt less when I am walking.
Unfortunately, my experience, and that of others, is that nothing works particularly well. There are some new drugs being investigated, but I don't see anything coming to market any time soon.
I have found that the most helpful thing for me is attitude. As time goes on, I have come to accept my condition more, and try to continue as much of my pre-PN life as possible, rather than succumb to the temptation to give up. Most importantly, I try not to become fearful of the future, which only serves to create more anxiety, resulting in an increase in symptoms.
Good luck, and I hope you find some relief from your pain.

Hi, has anyone ever heard of or tried an online drug called Nerve Renew? Chas