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DiscussionWhich prescription medication helps you best for peripheral neuropathy
Neuropathy | Last Active: Nov 15, 2021 | Replies (39)Comment receiving replies
Replies to "My question is. I have had peripheral polyneuropathy for 15 years and the best thing I..."
Hi @sport1776
I'm sorry for your suffering. I too have PN, so I can empathize.
The first step, as others have mentioned, is to get a specific diagnosis, as there are many forms of PN. Some of the forms of PN are treatable by addressing the underlying cause (if known). In my case, and many others, the cause remains unknown, even after an extensive work up (which is best done by a neurologist).
After the work up, the standard treatment is to start with gabapentin or pregabalin (Lyrica). They both act very much the same. The proper dose is determined by experimenting (with your doctor's advice).
Another commonly used medicine is some form of antidepressant, such as duloxitene (Cymbalta). Again, the proper dose varies with the individual. These types of medicines tend to have a dual effect. They help with depression, which many patients with PN develop. They also seem to have a separate analgesic effect.
There are numerous creams and lotions, some over the counter, that can be tried. Also, alternative methods such as acupuncture, meditation, supplements, vitamins, etc. Barry Shears in this forum discusses neuroplasticity.
It is important to maximize your physical surroundings. If your feet are burning, cool them, and vice-versa. Wear comfortable shoes (Ugg type boots help me the most). I wear flip flops whenever I can (even in the winter, but I live in moderate California). Also, I find my feet hurt less when I am walking.
Unfortunately, my experience, and that of others, is that nothing works particularly well. There are some new drugs being investigated, but I don't see anything coming to market any time soon.
I have found that the most helpful thing for me is attitude. As time goes on, I have come to accept my condition more, and try to continue as much of my pre-PN life as possible, rather than succumb to the temptation to give up. Most importantly, I try not to become fearful of the future, which only serves to create more anxiety, resulting in an increase in symptoms.
Good luck, and I hope you find some relief from your pain.
Hi, @sport1776, Gil, I am very fortunate to be among those who have p.n. but do not require medication yet for the pain.
As @loribmt and @amandajro suggested, there are some wonderful members on the p.n. site who have provided great suggestions on what has helped them over time as well as trusted links for more information about neuropathy. Wishing you the best and hoping that you'll find more aid for pain relief.
@sports1776. Welcome to Mayo Connect, Gil. On Mayo Connect we are not medical professionals and therefore we cannot diagnose health problems. However, we can share our own personal experiences. I’m sorry you’re having to go through all of this discomfort. Was your PN brought on by an event such as chemo or diabetes?
I’m going to bring into this conversation @johnbishop, @fiesty76, @jesfactsmon all of whom have had experience personally with PN or are a caregiver for someone who is dealing with this. Peripheral neuropathy is hot topic so I’m sure there will be many others in our community willing to share their stories and advice with you.
Here’s some information on PN to review in the meantime. https://www.mayoclinic.org/diseases-conditions/peripheral-neuropathy/symptoms-causes/syc-20352061?_ga=2.123822602.1027096109.1611755425-618629067.1611755425.