Hi @bustrbrwn22. Regarding your questions, they are somewhat hard to answer, as there are so many variables involved.
I do have some peripheral edema, which would contribute to weight gain, but I don't know for sure that either of the meds have caused it.
I also find that it is difficult for me to lose weight, even though I am trying to (I've even cut my usual 2 martini evening to 1).
I don't find that either causes anxiety. I do find that I am less upset by things that would normally really upset me, like current events, the Covid Plague, and of course, the PN. I don't think that I am depressed.
To tell you the truth, I am not sure whether any meds or other substances I am, or have, taken for PN help, which is a problem for me (and most others). Unless you have a clear cut result (one way or the other), it's nearly impossible to say whether what you are doing helps, makes you worse, or just doesn't do anything. It may just be the weather, or something your wife or husband did or said. It's not like treating, for example, high blood pressure, which you can measure.
My advice is to go to a good neurologist, follow the standard work up and treatment plan, and if you exhausted what is offered by traditional medicine, try some other things. Just be very careful about scams, unsupported claims, and advice you get from individuals about something that "worked" for them or someone they know.
Good luck!