Why all the fuss about B6 when it is water-soluble? Water-soluble vitamins are carried to the body's tissues but are not stored in the body. They are found in many plant and animal foods and in dietary supplements and must be taken in daily. Vitamin C and members of the vitamin B complex are water-soluble.
I had to take high doses of B6 for an extended period of time because of a genetic/health issue unrelated to neuropathy.