@jeaniebean I tried all the AI's and they all did horrible things to me. I think it's much more common than doctors acknowledge. An oncologists job is to take care of your cancer. Unfortunately, for many doctors that's where it stops. But quality of life is so important. I was early stage and had a bi lateral mastectomy - so my doctors weren't as concerned about the AI's. I felt like a big, black shadow covered me while on Letrozole and Tamoxifen. The pain was immediate and severe to my joints, especially my hands but the most worrisome was the mood alteration. I felt so depressed and disconnected. Ask for ongoing blood tests for your hormone levels, tumor markers, etc. You'll know if things are going 'sideways' that way and it might give you some calm knowing where you stand. I'm at five years now without cancer recurrance and holding, ha ha. Other problems are creeping up and it's patch, patch, patch but at least these past five years have been more tolerable without pain and mood problems. Hugs.