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Armando (@bolso1)

Vaccine against MAC?

MAC & Bronchiectasis | Last Active: Dec 20, 2020 | Replies (50)

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@irene5

So I am thinking Heather how one would vaccinate for MAC. It’s not contagious person to person like TB so it’s not like you would vaccinate the whole world. It would have to be something that targets the disease itself after a person gets it. I’d like to see that DNA research article in its entirety. What do you think? irene5

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Replies to "So I am thinking Heather how one would vaccinate for MAC. It’s not contagious person to..."

@irene so true, good thinking. Yes for after you have MAC, Im not sure, I feel meds or inhaling would be the best option but who knows, I havnt seen the DNA research.

I don't think that it would be necessary to vaccinate the whole world, nor that it would have to be administered after a person gets it. I think that we could make an analogy with the shingles/chickenpox situation (https://www.mayoclinic.org/diseases-conditions/shingles/symptoms-causes/syc-20353054), in that the vaccine against shingles is not given to the whole world but to those who are in higher risk groups. I think that in the same way that having developed a vaccine against chickenpox probably helped to develop a vaccine against shingles, the development of a vaccine against MAC could be aided by the experience with the vaccine against TB.
The demand for a vaccine against MAC has been increasing: In a 2011 paper (https://www.atsjournals.org/doi/full/10.1164/rccm.201111-2016OC) they studied a nationally representative 5% sample of Medicare Part B beneficiaries from 1997 to 2007, and found that the annual prevalence significantly increased from 20 to 47 cases/100,000 persons, or 8.2% per year. I wonder what has happened between 2007 and now, and compare it with, say, the increase in shingles.