@curtj
Curt, my wife who has neuropathy in her feet/ankles is also ultra sensitive and even allergic to most drugs. The only things that help the extreme bouts of pain are MJ (marijuana) and kratom, a leaf from SE Asia that can produce opiate-like qualities. And the kratom makes her so relaxed and out of it (sometimes for a whole day from just one dose) that she prefers the MJ. Meanwhile, in the quest for longer term pain relief she is experimenting with taking a supplement called PEA (Palmitoylethanolamide) which has a few studies where it has helped people with pain but jury is still out for my wife. Another member, @elizm , has had good success with it. Her profile page has her posts where she discusses it. Another thing my wife has been taking is a product called Theracurmin (supposedly a super curcumin) for inflammation. Inflammation causes long term bodily damage in pain sufferers. She is guardedly thinking that it has helped her so far. Like many here on Connect she has tried many things looking for relief and is still on the hunt after 6 years. In your wife's case I find it a hopeful sign that they have ruled out peripheral neuropathy. PN is usually intractable and chronic with no cure for most. But I know you guys would love to at least have a diagnosis. It's so frustrating to be in pain limbo with no answers. My heart goes out to you in a big way and I hope you are able to find answers and more importantly, relief for your wife's horrid pain. Best, Hank