Hi Sunnyflower, I learned about sarm1's role in nerve death and neuropathy from a webinar put on by the Foundation for Peripheral Neuropathy. The webinar concerned neuropathy arising after chemotherapy. I've never had chemotherapy but have been on plenty of other drugs that can be toxic, so I thought I might learn something useful.

Because Eli Lilly has acquired the technology from startup company Disarm, there are now deeper pockets to identify sarm1 inhibitors. My guess is that it will take years to identify and run clinical trials with candidate inhibitors.

However, the M.D. speakers also mentioned something else that may be useful in the short Term. Sarm1 is an enzyme that, among other things, breaks down NAD+ in damaged neurons. NAD+ is a type of energy currency used by neurons to carry out normal functions. If the neuron is depleted of NAD+, it kills the neuron causing pain along the way.

The doctors mentioned that there is a new supplement available called Tru Niagen or nicotinamide riboside. In your neurons, it is converted to NAD+, thereby compensating for the loss of NAD+ caused by activated sarm1. I've just started taking it. I have no idea if it will work. It's supposed to take 4-8 weeks. I've tried many diets, supplements and treatments for my neuropathy, so what's one more?

Re neuroplasticity, I underwent neurofeedback training for 2 years for epilepsy. It absolutely worked to help me bring my seizures under control. Unfortunately, it did nothing for my pain. Neuroplasticity/neurofeedback is a very useful tool. Make sure you get it from a practitioner who is certified.

Best wishes.

Margaret