Thank you so much for the quick reply beachdog! John's Whipple included removal of the pancreas head, lymph nodes, gall bladder, duodenum and a bit of the first part of the small intestine. He healed well from that and we were told diarrhea and weight gain would be long term issues, also that it can take a year for the body to adjust to its new plumbing. Between discussions with each expert (surgical team, oncology team, gastro team, kidney team, dietary team, colorectal team, etc.), it does seem like we need to figure things out for John's individual situation by trying things on our own to see what works/doesn't work. Right now he takes Immodium 30 minutes before each meal and we just added Benefiber to try and firm things up for better control. It seems to be working as long as he remains diligent about it. Since his small intestine is pretty much in tact, I don't understand why he isn't gaining weight - isn't this where most nutrient absorption occurs? The Creon is meant to manage this but maybe a study of how things pass through his system would be helpful - is this even a thing? I'm grateful for this forum as I know there are so many out there with various circumstances - any tidbit we can pick up at this point, or additional questions to pose to John's PCP - are helpful!