Hello @katherineanne, You will notice that we changed the title of your discussion to provide a little more information related to your questions to hopefully bring more members into the discussion. Your question is polyuria an after effect of prednisone hasn't been my experience in my two occurrences of PMR which has been in remission for the second time for about 2+ years...other than my sleep interrupted old man trips to the bathroom.

I did find some interesting information that mentions your symptoms and a potential link to diabetes -- Excerpt from article below - "Prednisolone had been discontinued 3 years prior to his current presentation. ... He complained of polyuria and polydipsia. ... Neurosarcoid, by causing both ACTH and ADH deficiency is one of the few conditions where the ADH deficiency is ..."
- Unmasking of diabetes insipidus with steroid treatment: https://www.endocrine-abstracts.org/ea/0015/ea0015p227

I am not aware of any new treatments for Polymyalgia Rheumatica (PMR). Here is an article from 2015 that discusses latest advances - Latest Advances in the Diagnosis and Treatment of Polymyalgia Rheumatica: https://www.practicalpainmanagement.com/pain/myofascial/inflammatory-arthritis/latest-advances-diagnosis-treatment-polymyalgia-rheumatica

I don't think there is a cure for it but after my first bout with PMR and while I was searching for information on another condition I have, small fiber peripheral neuropathy, I ran across a book by Dr. Terry Wahls - The Wahls Protocol. It put me on to eating healthier and the possibility that in itself can help with autoimmune conditions. Here's her story which prompted me to change my lifestyle - https://terrywahls.com/about/about-terry-wahls/

I try to exercise daily along with eliminating most processed foods and fast foods to help with my PMR like symptoms which I still have - morning aches and pains like a lot of the older generation 😊 Have you made any lifestyle changes to try and help with the pain, stiffness and fatigue?

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