Depends on your medical issues. They try to get all your appointments so you won't need to travel back to, in my case, Rochester. Sometimes they can but in some cases you may need to come back. It depends on individual circumstances. All my care was on an outpatient basis. I stayed at the Sleep Inn. There was daily Shuttle service to and from the Clinic, free of charge. It left the hotel at 20 minutes after the hour. You call the hotel directly for the Mayo Clinic rate.