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My Husband's journey with Glioblastoma

Brain Tumor | Last Active: Oct 21 5:20pm | Replies (174)

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@otis123

It has been a very rough few weeks. The re-radiation really took a toll on Steve's mobility, balance and short-term memory. He had to be increased to 16 mg of Dexamethasone (steroid) per day before starting to show improvement. An MRI showed a lot of swelling and also an increase in the size of the tumor. To compound issues, the Keytruda caused diarrhea and his other symptoms resulted in an urgency to go resulting in multiple "accidents". Due to the high dose of steroids, he cannot resume Keytruda, as they would counteract each other. He is still getting infusions of Avastin every other week, but it is very frustrating. Why is it that all these cancer drugs have to have such awful side effects.

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Replies to "It has been a very rough few weeks. The re-radiation really took a toll on Steve's..."

A decision has been made to try the chemo drug Lomustine instead of Keytruda. Steve will start next week. Hoping he has little or no side effects from this treatment. We are weaning him off the steroids slowly and Lomustine can be given at the same time. When we went to Duke for a second opinion, Lomustine is what they recommended after he didn't quality for their other clinical trial.