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My Husband's journey with Glioblastoma
Brain Tumor | Last Active: Oct 21, 2024 | Replies (174)Comment receiving replies
For now, Sloan Kettering did not have anything to compare with what Duke has to offer. Sloan has a Phase II/III study of Regorafenib Lomustine but Otie is ruled out because he has had two prior regimens of chemo, one of which was Avastin. In my search, I was looking for a Phase II or III trial as opposed to a Phase I. Most Phase I trials are trying to determine what is a safe dosage and frequency of drug to administer. I am hoping for something that has already proven to work----like the Duke D2C7 trial. As of this morning, we still have not heard back from Duke, and we are trying to breathe through the stress and anxiety of waiting.
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Well the phone call came late yesterday afternoon saying Otie was not eligible for the D2C7 trial at Duke because of outlying cells around his tumor that wouldn't allow the drug to be effective. They are suggesting Lomustine, which is confusing to me since Sloan Kettering seems to indicate that having treated with Avastin would rule out participation in a trial with Lomustine. I have asked Duke that question and will see what they say. So, basically, I am back to the drawing board if Lomustine gets ruled out. I really want to find a Phase II or III trial for a Gr IV Glioblastoma that has success with a non-methylated tumor. Anyone have any info? In the meantime, I will continue to search.